What is the Endocannabinoid System

And How Can CBD Help?

You might have heard about some of the transmitter systems that exist in human bodies. Without them, we simply could not function and it is crucial that they all work properly. One of them are neurotransmitters that, as the word suggests, have to do with our brain. Here’s where the endocannabinoid story starts.

For the past three decades, the endocannabinoid system has been a subject of much research and has been given significant attention, mostly because of its importance for the human body and potential health benefits.  In this article, you will find everything you need to know about this system: how it works, what parts it consists of, what its role is, and how CBD connects to all of it. Let’s start with the basics:

What is The Endocannabinoid System?

The endocannabinoid system is a complex biological system in the human body that consists of a vast network of chemical signals and cellular receptors and helps regulate and control a lot of crucial functions in the body – such as memory, sleep, emotions, pain control, or immune response for example.

Some research shows just how important the ECS is – so important it might be considered a ‘master regulator‘ in the body. Along with other transmitter systems in your body, ECS helps keep the homeostasis going and create optimal conditions for survival.

What Does This System Do?

The human brain has endocannabinoid receptors in the brain that are members of the G-protein-coupled receptor family, called CB1R and CB2R receptors. The first type is widely expressed and has versatile functions in the central nervous system, while the latter one is mostly considered to be a peripheral cannabinoid receptor.  There is talk among scientists that there might be a third receptor, but it hasn’t been proven yet.

These receptors are neurotransmitters or chemical messengers that send signals between nerve cells. They give immediate feedback and turn up (or down) the mechanism that needs adjusting.

Then they bind to the endocannabinoids – your body’s molecules that help keep internal functions running smoothly. They are similar to molecules in the cannabis plant, which is why cannabis works the way it works – it connects to its “ancestor” in our brain.

Then, there are the enzymes. After the molecules have bound to the receptors and did what they were supposed to do, the enzymes inside the ECS system work to break them down to prevent any buildup. There are two types of enzymes in this story – FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase).

All of these processes together create the endocannabinoid system we so desperately need. For example, without it – we couldn’t control our bodies’ temperature – this system regulates it when it’s out of the ordinary. Of course, since the endocannabinoid system is so vast, it helps with many other things in the human body – which is why it gets along so well with cannabinoid products you can legally buy.

How Does The Human Body Create Endocannabinoids?

Naturally, just like with any other internal system in the body. Endocannabinoids are present throughout the human body and can be found in various organs and tissues. They only become active when bound with a cannabinoid receptor – which will “tell” these molecules what needs to be fixed to maintain the optimal condition of the body.

What Does ECS Regulate?

We know that ECS’s part in the human body is important, but we still don’t know just how many things it helps regulate. For now, research shows that it may help regulate:

  • Appetite and digestion,
  • Sleep,
  • Pain control,
  • Inflammation and general immunity,
  • Mood,
  • Learning, and
  • Reproduction system function.

More research is needed before we can know all the details about the crucial part of the endocannabinoid system.

How Does CBD Affect the Endocannabinoid system?

As mentioned above, the human body naturally produces cannabinoid receptors – which is why they are then called endocannabinoid receptors. The word endo comes from the Greek word endon which means withing, internal.  So, naturally, just like our self-produced cannabinoids can bind to our self-produced cannabinoid molecules (endocannabinoids), the cannabinoids you buy work the same way. However, there is a difference between the cannabinoids found in cannabis – CBD and THC.

Just like one of the endocannabinoids called anandamide, THC binds to the CB1 receptors in the brain. But, the difference is, THC is psychoactive, not only calming like the anandamide. FAAH enzyme, the one that degrades the anandamide tries to degrade THC too, but it’s not as easy – which is why the “high” lasts as long.

CBD on the other hand, binds normally to both of the receptors (CB1 and CB2), without causing the “high” and bringing benefits to the entire body. Also, cannabidiol reduces the action of the FAAH enzyme, thus leaving a higher concentration of the anandamide in the system – which then brings benefits to the body – for example, its calming effect helps treat anxiety disorders. That might also answer your question on why you could use CBD if your body already produces it.

So, How Does CBD Affect Health?

As different researches mentioned above, CBD can bring benefits to your overall health condition. It interacts with neuroreceptors in our endocannabinoid system and sends signals between cells to help regulate movement, mood, the immune system, and overall homeostasis.  One of the biggest benefits CBD brings can be seen when treating some of the epilepsy syndromes that typically don’t respond to anti-seizure medication, like Dravet Syndrome and Lennox-Gastaut syndrome That’s why a specific drug containing CBD is approved by the FDA.  But, other than that, there are other things CBD can help you with when it comes to your overall health.

Claimed benefits of CBD*

  • CBD is proven to help offset anxiety and depression.
  • Reduces PTSD symptoms
  • Treats Opioid Addiction
  • Alleviates ALS Symptoms
  • Pain Relief
  • Better Sleep
  • Ease Diabetic Complications
  • Holds back Arthritis symptoms
  • It May have neuroprotective properties
  • Might Lower Blood Pressure

* Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/ , https://www.jyi.org/2018-june/2018/6/1/the-endocannabinoid-system-our-universal-regulator , https://www.health.harvard.edu/blog/the-endocannabinoid-system-essential-and-mysterious-202108112569

Side effects

Even though CBD is legal in the US and is generally well-tolerated, it still may cause some side effects in some people, especially in the beginning. They are mostly connected to dry mouth, diarrhea, changes in appetite and weight, and fatigue.

It is important to do your research before buying a certain product. The quality of the product might also be connected with whether you will have any side effects. Furthermore, the dosage of the product is not the same for everyone or every condition. Since CBD may cause fatigue, you should be careful when it comes to driving or doing any risky activities.

What Type of Products Should I Use?

CBD comes in many forms. You can choose between topicals, oils, capsules, patches, vapes, and more. It can be found in food, makeup products, ointments, skincare, and even anti-anxiety products for pets. Apart from the CBD isolate, which is a pure form of CBD with no other compounds from the cannabis plant, there are full and broad-spectrum products as well.

Full-spectrum CBD

Full-spectrum CBD has all the components of the cannabis plant, including a small amount of THC. Even though it’s federally legal for the product to have 0.3% of THC, you still have to know the exact percentage a product has, not only for legal reasons among states but because of combining with medications as well. Since THC is a psychoactive component, you might experience the “high”.

Broad-spectrum CBD

Unlike CBD isolate that has no other compounds from the plant, broad-spectrum CBD is a version that has all of the components of a cannabis plant, EXCEPT the THC. So, if you want to avoid any potential intoxication from THC and reap all the benefits, opt for this one.

How To Choose A CBD Product?

That depends on your preferences and what you’re seeking help for. For example – tinctures and oils might work for you if you have trouble swallowing pills since they are placed under the tongue. Creams and lotions are good for treating muscle and joint pain and might also help with treating certain skin conditions. Pills are used mostly for seizure disorders, while edibles are among the most popular ways. Vaping is the fastest way to experience the effects.

When it comes to dosage, you should start slow and increase your dose with time. If you’re still new to the CBD world and are experimenting with various brands, make sure to make a well-informed purchase first, since there might be variations. Read product labels and consult with your doctor.

Taking CBD with Medications

As mentioned, even if it’s considered safe, CBD might cause drowsiness and fatigue, so if you take other medication with the same side effects, there is a risk of increasing those conditions when combining the two products.

This is because drugs are often broken down by enzymes in the liver. CBD could compete with these enzymes and in turn – your medication might not work, or the side effects could be increased. Penn State Health conducted research and identified 57 medications that might be affected by cannabinoids. However, while doing the research, they tested both THC and CBD cannabinoid medications, so some of the medications on the list are not affected by CBD, only THC. Still, if you are on blood thinners, a heart rhythm medication, a thyroid medication, or medications for seizures, you should be cautious if you decide to start using CBD.

The form of CBD you want to use matters, too. Inhaled CBD and edibles can interact with other medications much sooner than other products. Topical products, on the other hand, may not absorb in the blood as much to cause problems with other medication.

If you’re taking prescribed medication and are thinking of starting using CBD, consult with your doctor first.

Conclusion

The endocannabinoid system has proven to be one of the most important parts of the human body. Its important role in our day-to-day life is still one of the biggest topics that is yet to be fully explored. However, there is enough research that shows the benefits of its as well as the benefits of using CBD. We know our bodies produce their own cannabinoids that work in sync with other endocrine systems of the human body and help maintain homeostasis.

Thanks to the research conducted so far, the federal government legalized hemp products in the US as well as the manufacturing of CBD. Of course, there are some restrictions, but when it comes to OH Sapiens products, you can rest assured that all of those restrictions are followed and respected. Grown and harvested on our farm, you can trust that your CBD is 100% clean and safe, and is of a quality you won’t experience anywhere else.

What is the Endocannabinoid System

And How CBD Can Help?

You might have heard about some of the transmitter systems that exist in human bodies. Without them, we could literally not function and it is crucial that they all work properly. One of them are neurotransmitters that, as the word suggests, have to do with our brain. Here’s where the endocannabinoid story starts.

For the past three decades, the endocannabinoid system has been a subject of much research and has been given significant attention, mostly because of its importance for the human body and potential health benefits.  In this article, you will find everything you need to know about this system: how it works, what parts it consists of, what its role is, and how CBD connects to all of it. Let’s start with the basics:

What is The Endocannabinoid System?

The endocannabinoid system is a complex biological system in the human body that consists of a vast network of chemical signals and cellular receptors and helps regulate and control a lot of crucial functions in the body – such as memory, sleep, emotions, pain control, or immune response for example. Some research shows just how important the ECS is – so important it might be considered a ‘master regulator‘ in the body. Along with other transmitter systems in your body, ECS helps keep the homeostasis going and create optimal conditions for survival.

What Does This System Do Exactly?

The human brain has endocannabinoid receptors in the brain that are members of the G-protein-coupled receptor family, called CB1R and CB2R receptors. The first type is widely expressed and has versatile functions in the central nervous system, while the latter one is mostly considered to be a peripheral cannabinoid receptor.  There is talk among scientists that there might be a third receptor, but that’s not been proven yet.

These receptors are neurotransmitters or chemical messengers that send signals between nerve cells. They give immediate feedback and turn up (or down) whatever activity needs adjusting.

Then they bind to the endocannabinoids – your body’s molecules that help keep internal functions running smoothly. They are similar to molecules in the cannabis plant, which is why cannabis works the way it works – it connects to its “ancestor” in our brain.

Then, there are the enzymes. After the molecules have bound to the receptors and did what they were supposed to do, the enzymes inside the ECS system work to break them down to prevent any buildup. There are two types of enzymes in this story – FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase).

All of these processes together create the endocannabinoid system we so desperately need. For example, without it – we couldn’t control our bodies’ temperature – this system regulates it when it’s out of the ordinary. Of course, since the endocannabinoid system is so vast, it helps with many other things in the human body – which is why it gets along so well with cannabinoid products you can legally buy.

How Does The Human Body Create Endocannabinoids?

Naturally, just like with any other internal system in the body. Endocannabinoids are present throughout the human body and can be found in various organs and tissues. They only become active when bound with a cannabinoid receptor – which will “tell” these molecules what needs to be fixed to maintain the optimal condition of the body.

What Does ECS Regulate?

We know that ECS’s part in the human body is important, but we still don’t know just how many things it helps regulate. For now, research shows that it may help regulate:

  • Appetite and digestion,
  • Sleep,
  • Pain control,
  • Inflammation and general immunity,
  • Mood,
  • Learning, and
  • Reproduction system function.

A lot more research is still needed before we can know all the details about the crucial part of the endocannabinoid system.

How Does CBD Affect the Endocannabinoid system?

As mentioned above, the human body naturally produces cannabinoid receptors – which is why they are then called endocannabinoid receptors. The word endo comes from the Greek word endon which means withing, internal.  So, naturally, just like our self-produced cannabinoids can bind to our self-produced cannabinoid molecules (endocannabinoids), the cannabinoids you buy work the same way. However, there is a difference between the cannabinoids found in cannabis – CBD and THC.

Just like one of the endocannabinoids called anandamide, THC binds to the CB1 receptors in the brain. But, the difference is, THC is psychoactive, not only calming like the anandamide. FAAH enzyme, the one that degrades the anandamide tries to degrade THC too, but it’s not as easy – which is why the “high” lasts as long.

CBD on the other hand, binds normally to both of the receptors (CB1 and CB2), without causing the “high” and bringing benefits to the entire body. Also, cannabidiol reduces the action of the FAAH enzyme, thus leaving a higher concentration of the anandamide in the system – which then brings benefits to the body – for example, its calming effect helps treat anxiety disorders. That might also answer your question on why you could use CBD if your body already produces it.

So, How Does CBD Affect Health?

As different researches mentioned above, CBD can bring benefits to your overall health condition. It interacts with neuroreceptors in our endocannabinoid system and sends signals between cells to help regulate movement, mood, the immune system, and overall homeostasis.  One of the biggest benefits CBD brings can be seen when treating some of the epilepsy syndromes that typically don’t respond to anti-seizure medication, like Dravet Syndrome and Lennox-Gastaut syndrome That’s why a specific drug containing CBD is approved by the FDA.  But, other than that, there are other things CBD can help you with when it comes to your overall health.

Claimed benefits of CBD

(according to research studies)
  • CBD is proven to help offset anxiety and depression.
  • Reduces PTSD symptoms
  • Treats Opioid Addiction
  • Alleviates ALS Symptoms
  • Pain Relief
  • Better Sleep
  • Ease Diabetic Complications
  • Holds back Arthritis symptoms
  • It May have neuroprotective properties
  • Might Lower Blood Pressure

Side effects

Even though CBD is legal in the US and is generally well-tolerated, it still may cause some side effects in some people, especially in the beginning. They are mostly connected to dry mouth, diarrhea, changes in appetite and weight, and fatigue. Of course, it’s important to do your research before buying a certain product. The quality of the product might also be connected with whether you will have any side effects. Furthermore, the dosage of the product is not the same for everyone or every condition. Since CBD may cause fatigue, you should be careful when it comes to driving or doing any risky activities.

What Type of Products Should I Use?

CBD comes in many forms. You can choose between topicals, oils, capsules, patches, vapes, and more. It can be found in food, makeup products, ointments, skincare, and even anti-anxiety products for pets. Apart from the CBD isolate, which is a pure form of CBD with no other compounds from the cannabis plant, there are full and broad-spectrum products as well.

Full-spectrum CBD

Full-spectrum CBD has all the components of the cannabis plant, including a small amount of THC. Even though it’s federally legal for the product to have 0.3% of THC, you still have to know the exact percentage a product has, not only for legal reasons among states but because of combining with medications as well. Since THC is a psychoactive component, you might experience the “high”.

Broad-spectrum CBD

Unlike CBD isolate that has no other compounds from the plant, broad-spectrum CBD is a version that has all of the components of a cannabis plant, EXCEPT the THC. So, if you want to avoid any potential intoxication from THC and reap all the benefits, opt for this one.

How To Choose A CBD Product?

That depends on your preferences and what you’re seeking help for. For example – tinctures and oils might work for you if you have trouble swallowing pills since they are placed under the tongue. Creams and lotions are good for treating muscle and joint pain and might also help with treating certain skin conditions. Pills are used mostly for seizure disorders, while edibles are among the most popular ways. Vaping is the fastest way to experience the effects.

When it comes to dosage, you should start slow and increase your dose with time. If you’re still new to the CBD world and are experimenting with various brands, make sure to make a well-informed purchase first, since there might be variations. Read product labels and consult with your doctor.

Taking CBD with Medications

As mentioned, even if it’s considered safe, CBD might cause drowsiness and fatigue, so if you take other medication with the same side effects, there is a risk of increasing those conditions when combining the two products.

This is because drugs are often broken down by enzymes in the liver. CBD could compete with these enzymes and in turn – your medication might not work, or the side effects could be increased. Penn State Health conducted research and identified 57 medications that might be affected by cannabinoids. However, while doing the research, they tested both THC and CBD cannabinoid medications, so some of the medications on the list are not affected by CBD, only THC. Still, if you are on blood thinners, a heart rhythm medication, a thyroid medication, or medications for seizures, you should be cautious if you decide to start using CBD.

The form of CBD you want to use matters, too. Inhaled CBD and edibles can interact with other medications much sooner than other products. Topical products, on the other hand, may not absorb in the blood as much to cause problems with other medication.

If you’re taking prescribed medication and are thinking of starting using CBD, consult with your doctor first.

Conclusion

The endocannabinoid system has proven to be one of the most important parts of the human body. Its important role in our day-to-day life is still one of the biggest topics that is yet to be fully explored. However, there is enough research that shows the benefits of its as well as the benefits of using CBD. We know our bodies produce their own cannabinoids that work in sync with other endocrine systems of the human body and help maintain homeostasis.

Thanks to the research conducted so far, the federal government legalized hemp products in the US as well as the manufacturing of CBD. Of course, there are some restrictions, but when it comes to OH Sapiens products, you can rest assured that all of those restrictions are followed and respected. Grown and harvested on our farm, you can trust that your CBD is 100% clean and safe, and is of a quality you won’t experience anywhere else.

Shop Our Full Selection of Products